2008 Guidelines from the
American College of Chest Physicians
recommend ARIXTRA® (fondaparinux sodium) Injection
1A recommendations across all of its
FDA-approved indications*
Click on an indication in chart below to learn more.
| Venous thromboembolism (VTE)treatment | Grade |
|---|---|
| Deep vein thrombosis (DVT)
When administered in conjunction with warfarin |
1A |
| Pulmonary embolism (PE)
When administered in conjunction with warfarin when initial therapy is started in the hospital |
1A |
| VTE prophylaxis | |
| Hip fracture surgery | 1A |
| Hip fracture surgery including extended prophylaxis |
1A |
| Knee replacement surgery | 1A |
| Hip replacement surgery | 1A |
| Abdominal surgery
For patients at risk for thrombotic complications |
1A* |
ARIXTRA is contraindicated in patients with severe renal impairment (creatinine clearance <30 mL/min) and for prophylaxis in patients <50 kg.
*Abdominal Surgery Indication is included generally in section 2.1.2 and 2.1.3 in ACCP guidelines regarding general surgery on pages 395S-396S.
In addition to recommending ARIXTRA, ACCP Guidelines also include the following recommendations for the following surgeries and conditions:
- Elective total hip replacement: LMWH and vitamin K antagonist (VKA) are recommended with a grade of 1A
- Total knee replacement: LMWH and VKA are recommended with a grade of 1A
- Hip fracture surgery: LMWH, VKA, or LDUH are recommended with a grade of 1B
- Hip fracture surgery with extended prophylaxis: LMWH and VKA are recommended with a grade of 1C
- Confirmed DVT and PE: initial treatment with subcutaneous LMWH, intravenous UFH, and subcutaneous UFH are recommended with a grade of 1A
- Acute DVT and PE: VKA together with LMWH, UFH, or ARIXTRA are recommended with a grade of 1A
About ACCP Guidelines recommendations [21]:
- Grades of 1 or 2 respectively confer a strong or weaker recommendation
- Grades of A, B, or C respectively indicate high-quality evidence, moderate-quality evidence, or low-quality evidence
Click here, for more information on the 2008 ACCP Guidelines.