2008 Guidelines from the
American College of Chest Physicians
recommend ARIXTRA® (fondaparinux sodium) Injection
1A recommendations across all of its
FDA-approved indications*
Click on an indication in chart below to learn more.
| Venous thromboembolism (VTE)treatment | Grade |
|---|---|
| Deep vein thrombosis (DVT) † | 1A |
| Pulmonary embolism (PE) †‡ | 1A |
| VTE prophylaxis | |
| Hip fracture surgery | 1A |
| Hip fracture surgery including extended prophylaxis |
1A |
| Knee replacement surgery | 1A |
| Hip replacement surgery | 1A |
| Abdominal surgery § | 1A* |
ARIXTRA is contraindicated in patients with severe renal impairment (creatinine clearance <30 mL/min) and for prophylaxis in patients <50 kg.
*Abdominal Surgery Indication is included generally in section 2.1.2 and 2.1.3 in ACCP guidelines regarding general surgery on pages 395S-396S.
†When administered in conjunction with warfarin.
‡When initial therapy is started in the hospital.
§For patients at risk for thrombotic complications.
In addition to recommending ARIXTRA, ACCP Guidelines also include the following recommendations for the following surgeries and conditions:
- Elective total hip replacement: LMWH and vitamin K antagonist (VKA) are recommended with a grade of 1A
- Total knee replacement: LMWH and VKA are recommended with a grade of 1A
- Hip fracture surgery: LMWH, VKA, or LDUH are recommended with a grade of 1B
- Hip fracture surgery with extended prophylaxis: LMWH and VKA are recommended with a grade of 1C
- Confirmed DVT and PE: initial treatment with subcutaneous LMWH, intravenous UFH, and subcutaneous UFH are recommended with a grade of 1A
- Acute DVT and PE: VKA together with LMWH, UFH, or ARIXTRA are recommended with a grade of 1A
About ACCP Guidelines recommendations [21]:
- Grades of 1 or 2 respectively confer a strong or weaker recommendation
- Grades of A, B, or C respectively indicate high-quality evidence, moderate-quality evidence, or low-quality evidence
Click here, for more information on the 2008 ACCP Guidelines.